| IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. | |
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MedLine Citation:
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PMID: 21493143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17, a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is required for IL-17-mediated signaling. Here, we review the molecular and cellular mechanisms by which IL-17 and Act1-mediated signaling contribute to EAE. |
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Authors:
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Jarod Zepp; Ling Wu; Xiaoxia Li |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-04-12 |
Journal Detail:
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Title: Trends in immunology Volume: 32 ISSN: 1471-4981 ISO Abbreviation: Trends Immunol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-09 Completed Date: 2011-09-06 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 232-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Immunology, Cleveland Clinic Cleveland, OH 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases* / immunology, pathology Demyelinating Diseases* / immunology, pathology Encephalomyelitis, Autoimmune, Experimental / immunology, pathology Humans Mice Multiple Sclerosis / immunology, pathology Receptors, Interleukin-17 / metabolism* Signal Transduction* Th17 Cells / immunology* Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS071996-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-17; 0/TRAF3IP2 protein, human; 0/Tumor Necrosis Factor Receptor-Associated Peptides and Proteins |
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