| IL-17 inhibits human Th1 differentiation through IL-12R beta 2 downregulation. | |
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MedLine Citation:
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PMID: 19692269 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Th17 cells are critical in adaptive immunity and autoimmune disease. The polarized development of Th17, Th1 and Th2 cells is dependent on counterregulatory effects on each other. Whereas IFN-gamma inhibits Th17 development, the effect of IL-17 in human Th1 development is not known. We report a novel negative regulatory role of IL-17 on IL-12R beta 2 expression associated with reduced IL-12 responsiveness. IL-17 decreased IL-12-induced IFN-gamma expression in PBMC and developing Th1 cells, associated with a selective reduction in IL-12R beta 2, and not IL-23R, IL-12R beta 1 or T-bet. Counterregulatory effects of human Th17 on Th1 lineage cytokines may contribute to lineage divergence. In autoimmune disease, IL-17 may reinforce its own developmental programme by reducing IL-12 responsiveness, thus limiting inhibitory effects of IFN-gamma on Th17 development. |
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Authors:
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Myew-Ling Toh; Masanori Kawashima; Saloua Zrioual; Arnaud Hot; Philippe Miossec; Pierre Miossec |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-18 |
Journal Detail:
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Title: Cytokine Volume: 48 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 226-30 Citation Subset: IM |
Affiliation:
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Department of Immunology, University of Lyon, Edouard Herriot Hospital, Lyon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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