| IL-17 in sera from patients with aggressive periodontitis. | |
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MedLine Citation:
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PMID: 20400718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-17 (IL-17), the prototype cytokine produced by the Th17 subset of T-helper cells, plays a role in inflammatory responses, autoimmunity, and antimicrobial responses in a variety of infectious and inflammatory diseases. In view of the inflammatory nature and severity of aggressive periodontitis, we hypothesized that IL-17 might be detected in sera from patients with aggressive periodontitis. We used ELISA to measure IL-17 serum concentrations from 67 periodontally healthy (NP) individuals and from 53 patients with localized (LAgP) and 49 patients with generalized (GAgP) aggressive periodontitis. IL-17 was barely detectable in sera from periodontally healthy individuals (1.9 +/- 2.0 pg/mL), but was present at significantly higher concentrations in sera from those with LAgP (7.6 +/- 2.2 pg/mL) and GAgP (17.1 +/- 2.3 pg/mL). Multivariate analyses demonstrated associations of IL-17 concentrations with periodontal attachment loss, but not with current smoking. Therefore, Th17 responses may be characteristic of AgP, and IL-17 may play a role in the pathogenesis of aggressive periodontitis. |
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Authors:
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H A Schenkein; T E Koertge; C N Brooks; R Sabatini; D E Purkall; J G Tew |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2010-04-16 |
Journal Detail:
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Title: Journal of dental research Volume: 89 ISSN: 1544-0591 ISO Abbreviation: J. Dent. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-09-23 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 943-7 Citation Subset: D; IM |
Affiliation:
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Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298-0566, USA. haschenk@vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Aggressive Periodontitis / blood*, immunology* Analysis of Variance Case-Control Studies Female Gingiva / immunology Humans Interleukin-17 / blood* Male Periodontal Attachment Loss / blood Periodontal Index Regression Analysis T-Lymphocytes, Helper-Inducer / immunology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DE018125/DE/NIDCR NIH HHS; MD002256/MD/NCMHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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