| IL-17 and Th17 cells in tuberculosis. | |
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MedLine Citation:
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PMID: 21075039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in this organ is required to control Mycobacterium tuberculosis growth, but this can also result in chronic inflammation and pathologic consequences. During primary tuberculosis both IFN-γ and IL-17 are induced: both are potent inflammatory cytokines capable of inducing expression of chemokines that promote cell recruitment and granuloma organization throughout infection. During the chronic phase, a balance between Th1 and Th17 responses needs to be achieved to control bacterial growth and limit immunopathology, as a shift of the response towards excessive IL-17 production may sustain extensive neutrophil recruitment and tissue damage. Thus, regulation of Th1 and Th17 responses during tuberculosis is essential to promote anti-mycobacterial immunity and prevent extensive immunopathological consequences. |
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Authors:
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Egídio Torrado; Andrea M Cooper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-11-12 |
Journal Detail:
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Title: Cytokine & growth factor reviews Volume: 21 ISSN: 1879-0305 ISO Abbreviation: Cytokine Growth Factor Rev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-11 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9612306 Medline TA: Cytokine Growth Factor Rev Country: England |
Other Details:
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Languages: eng Pagination: 455-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Trudeau Institute, Inc., 154 Algonquin Ave., Saranac Lake, NY 12983, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals BCG Vaccine / immunology Cell Differentiation Humans Interferon-gamma / immunology Interleukin-17 / immunology* Interleukins / immunology Lung / immunology Mice Th17 Cells / immunology* Tuberculosis / immunology*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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AI46530/AI/NIAID NIH HHS; AI67723/AI/NIAID NIH HHS; AI69121/AI/NIAID NIH HHS; P01 AI046530-04/AI/NIAID NIH HHS; R01 AI067723-05/AI/NIAID NIH HHS; R01 AI069121-04/AI/NIAID NIH HHS; R37 AG025805-08/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/BCG Vaccine; 0/Interleukin-17; 0/Interleukins; 0/interleukin-22; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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