Document Detail


Is IL-17 Involved in the Interaction Between Polycystic Ovary Syndrome and Gingival Inflammation?
MedLine Citation:
PMID:  23327719     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:Polycystic ovarian syndrome (PCOS) is a hormonal disorder of women of reproductive age that impacts on their oral and systemic health. The aim of this study was to evaluate interleukin-17A (IL-17A), IL-17F, IL-17A/F and IL-17E (IL-25) levels in gingival crevicular fluid (GCF), saliva and serum of non-obese women with PCOS and with either a clinically healthy periodontium or gingivitis. Materials & Methods: Thirty-one women with PCOS, 30 women with PCOS and gingivitis and 12 systemically and periodontally healthy women participated in the study. Clinical periodontal measurements, body mass index (BMI) and Ferriman-Gallwey score (FGS) (a measure of hirsuitism in women) were recorded. Circulating levels of sex hormones, cortisol and insulin were also determined. Levels of IL-17 cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Results: The General linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of: IL-17A, IL-17F and IL-17A/F in serum; higher levels of IL-17A and IL-17F in GCF and saliva but lower serum IL-17E than systemically healthy women. Levels of IL-17E were lowest in women with PCOS and gingivitis who also had the highest FGS. Serum IL-17A and IL-17F levels correlated positively with FGS and periodontal pocket depth (all: rho >0.33; p<0.005). Serum IL-17E showed the reverse relationship and also correlated negatively with IL-17A (rho> -0.28; p<0.05). Conclusion: IL-17 levels are altered in non-obese women with PCOS and may influence gingival inflammation. Further studies are warranted to clarify the relationship between PCOS and gingivitis.
Authors:
Ozgün Ozçaka; Nurcan Buduneli; Banu Ozturk Ceyhan; Aliye Akcali; Victoria Hannah; Christopher Nile; David F Lappin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Periodontology, School of Dentistry.
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