Document Detail

IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis.
MedLine Citation:
PMID:  16316662     Owner:  NLM     Status:  MEDLINE    
Interleukin-15 (IL-15) is a novel proinflammatory cytokine having similar biological activities to IL-2 which is implicated in the pathogenesis of multiple sclerosis. It is produced by activated blood monocytes, macrophages and glial cells. There is little information about the involvement of IL-15 in the development of multiple sclerosis (MS). The objective of our study was to measure IL-15 serum and cerebrospinal fluid (CSF) levels in MS patients and to correlate serum and CSF IL-15 concentrations with clinical parameters of the disease. CSF IL-15/Serum IL-15 ratio (c/s IL-15 ratio) was introduced to assess the origin of elevated IL-15 levels. MATERIALS AND METHODS: We measured serum and CSF IL-15 levels in 52 patients with MS and 36 age and gender matched patients with inflammatory (IND) and non-inflammatory neurological diseases (NIND) studied as control groups. IL-15 levels were correlated with clinical parameters as duration, disability, MRI activity and clinical subtypes of the disease. RESULTS: MS patients were found to have significantly higher serum IL-15 levels compared with IND (p=0.00016) and NIND patients (p=0.00045). Elevated levels of IL-15 were also found in CSF samples from MS patients compared with patients with IND (p=0.00034) and NIND (p=0.0003). Among MS subgroups there were no statistically different IL-15 serum and CSF concentrations. No significant correlation of serum and CSF IL-15 concentrations with MRI activity, disability assessed by EDSS score and duration of the disease were also found. C/S IL-15 ratio was found lower in MS patients compared with IND (p=0.01) and not significantly different compared with NIND patients (p=0.14) suggesting that systemic activation might be the source of high CSF IL-15 levels in MS patients. CONCLUSIONS: Our findings suggest a possible role of IL-15 in the immunopathogenetic mechanisms of MS.
M Rentzos; C Cambouri; A Rombos; C Nikolaou; M Anagnostouli; A Tsoutsou; A Dimitrakopoulos; N Triantafyllou; D Vassilopoulos
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-11-28
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  241     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Department of Neurology, Aeginition Hospital-Athens Medical School, 72-74 Vas.So phias Av, Greece.
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MeSH Terms
Case-Control Studies
Enzyme-Linked Immunosorbent Assay / methods
Interleukin-5 / blood*,  cerebrospinal fluid*
Middle Aged
Multiple Sclerosis / blood*,  cerebrospinal fluid*
Nervous System Diseases / blood,  cerebrospinal fluid
Statistics, Nonparametric
Reg. No./Substance:

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