Document Detail

IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice.
MedLine Citation:
PMID:  23161867     Owner:  NLM     Status:  MEDLINE    
Endurance exercise initiates a pattern of gene expression that promotes fat oxidation, which in turn improves endurance, body composition, and insulin sensitivity. The signals from exercise that initiate these pathways have not been completely characterized. IL-15 is a cytokine that is up-regulated in skeletal muscle after exercise and correlates with leanness and insulin sensitivity. To determine whether IL-15 can induce any of the metabolic adaptations associated with exercise, substrate metabolism, endurance, and molecular expression patterns were examined in male transgenic mice with constitutively elevated muscle and circulating IL-15 levels. IL-15 transgenic mice ran twice as long as littermate control mice in a run-to-exhaustion trial and preferentially used fat for energy metabolism. Fast muscles in IL-15 transgenic mice exhibited high expression of intracellular mediators of oxidative metabolism that are induced by exercise, including sirtuin 1, peroxisome proliferator-activated receptor (PPAR)-δ, PPAR-γ coactivator-1α, and PPAR-γ coactivator-1β. Muscle tissue in IL-15 transgenic mice exhibited myosin heavy chain and troponin I mRNA isoform expression patterns indicative of a more oxidative phenotype than controls. These findings support a role for IL-15 in induction of exercise endurance, oxidative metabolism, and skeletal muscle molecular adaptations induced by physical training.
Lebris S Quinn; Barbara G Anderson; Jennifer D Conner; Tami Wolden-Hanson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-16
Journal Detail:
Title:  Endocrinology     Volume:  154     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-02-22     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-45     Citation Subset:  AIM; IM    
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MeSH Terms
Energy Metabolism / genetics,  physiology*
Interleukin-15 / genetics,  metabolism*
Mice, Transgenic
Muscle, Skeletal / metabolism*
Myosin Heavy Chains / genetics
PPAR delta / genetics*
Sirtuin 1 / genetics*
Trans-Activators / genetics*
Transcription Factors
Troponin I / genetics
Grant Support
5P30AG-013280/AG/NIA NIH HHS; P30 AG013280/AG/NIA NIH HHS; P30 DK-17047/DK/NIDDK NIH HHS; R01AG024136/AG/NIA NIH HHS
Reg. No./Substance:
0/Interleukin-15; 0/PPAR delta; 0/Ppargc1a protein, mouse; 0/Trans-Activators; 0/Transcription Factors; 0/Troponin I; EC 3.5.1.-/Sirt1 protein, mouse; EC 3.5.1.-/Sirtuin 1; EC Heavy Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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