| IL-12 and related cytokines: function and regulatory implications in Candida albicans infection. | |
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MedLine Citation:
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PMID: 21052539 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them. |
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Authors:
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Robert B Ashman; Dipti Vijayan; Christine A Wells |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-01 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2011 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 686597 Citation Subset: IM |
Affiliation:
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The School of Dentistry, University of Queensland School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia. r.ashman@uq.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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