| IL-12 and IL-10 production are differentially regulated by phosphatidylinositol 3-kinase in mast cells. | |
| | |
MedLine Citation:
|
PMID: 22023709 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The cellular mechanisms that directly regulate the production of pro- and anti-inflammatory cytokines after lipopolysaccharide (LPS) stimulation in mast cells are currently unresolved. The aim of this study was to clarify the role of phosphatidylinositol 3-kinase (PI3K) in the production of IL-12 and IL-10 in mouse bone marrow-derived mast cells (BMMCs) stimulated with E. coli-derived LPS. LPS activates the PI3K signaling pathway; analysis of cytokine production following LPS stimulation of BMMCs revealed that inhibition of the PI3K pathway differentially regulated IL-10 and IL-12 synthesis. IL-12 production was enhanced, whereas IL-10 levels were suppressed. Inhibition of LPS-mediated activation of the PI3K pathway resulted in a pronounced reduction of NF-κB activity that was dependent on IκBα phosphorylation. These findings demonstrate a regulatory function for PI3K in modulating IL-10 and IL-12 production in mast cells, and provide insight into how engagement of the PI3K pathway affects the induction of key immunoregulatory cytokines that control both qualitative and quantitative aspects of early inflammation. |
| | |
Authors:
|
Chuanwang Song; Qingchuan Zhang; Xiaolong Liu; Yuxi Shan |
Related Documents
:
|
10627389 - Mycoplasma gallisepticum -induced release of macrophage inflammatory protein-1 beta fro... 21086009 - The effect of a single episode of antimicrobial photodynamic therapy in the treatment o... 17250589 - Expression of gm1, a marker of lipid rafts, defines two subsets of human monocytes with... 1761359 - Application of purified polysaccharides from cell cultures of the plant echinacea purpu... 1960409 - Measurement of cytokine production by the monocytic cell line mono mac 6 using novel im... 11720009 - Matrix metalloproteinase and cytokine profiles in monocytes over the course of stroke. 16424939 - Peptide vaccination of mice immune to lcmv or vaccinia virus causes serious cd8 t cell-... 18329009 - Neuroendocrine factors alter host defense by modulating immune function. 19022819 - The pi3k/akt/mtor pathway in innate immune cells: emerging therapeutic applications. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-25 |
Journal Detail:
|
Title: Scandinavian journal of immunology Volume: - ISSN: 1365-3083 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Immunology, Bengbu Medical College, Bengbu, Anhui, China Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viral infections associated with the clinical use of monoclonal antibodies.
Next Document: How sweet it is to be loved by you: The role of perceived regard in the terror management of close r...