| IL-10 within the CNS is necessary for CD4(+) T cells to mediate neuroprotection. | |
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MedLine Citation:
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PMID: 20723599 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We have previously shown that immunodeficient mice exhibit significant facial motoneuron (FMN) loss compared to wild-type (WT) mice after a facial nerve axotomy. Interleukin-10 (IL-10) is known as a regulatory cytokine that plays an important role in maintaining the anti-inflammatory environment within the central nervous system (CNS). IL-10 is produced by a number of different cells, including Th2 cells, and may exert an anti-apoptotic action on neurons directly. In the present study, the role of IL-10 in mediating neuroprotection following facial nerve axotomy in Rag-2- and IL-10-deficient mice was investigated. Results indicate that IL-10 is neuroprotective, but CD4(+) T cells are not the requisite source of IL-10. In addition, using real-time PCR analysis of laser microdissected brainstem sections, results show that IL-10 mRNA is constitutively expressed in the facial nucleus and that a transient, significant reduction of IL-10 mRNA occurs following axotomy under immunodeficient conditions. Dual labeling immunofluorescence data show, unexpectedly, that the IL-10 receptor (IL-10R) is constitutively expressed by facial motoneurons, but is selectively induced in astrocytes within the facial nucleus after axotomy. Thus, a non-CD4(+) T cell source of IL-10 is necessary for modulating both glial and neuronal events that mediate neuroprotection of injured motoneurons, but only with the cooperation of CD4(+) T cells, providing an avenue of novel investigation into therapeutic approaches to prevent or reverse motoneuron diseases, such as amyotrophic lateral sclerosis (ALS). |
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Authors:
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Junping Xin; Derek A Wainwright; Nichole A Mesnard; Craig J Serpe; Virginia M Sanders; Kathryn J Jones |
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Publication Detail:
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Type: Journal Article Date: 2010-08-17 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 25 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 820-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153, United States; Research and Development Service, Hines VA Hospital, Hines, IL 60141, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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