|IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization.|
|PMID: 10811896 Owner: NLM Status: MEDLINE|
|Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.|
|M J Mäkelä; A Kanehiro; L Borish; A Dakhama; J Loader; A Joetham; Z Xing; M Jordana; G L Larsen; E W Gelfand|
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|Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.|
|Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 97 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2000 May|
|Created Date: 2000-06-30 Completed Date: 2000-06-30 Revised Date: 2009-11-18|
Medline Journal Info:
|Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES|
|Languages: eng Pagination: 6007-12 Citation Subset: IM|
|Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.|
|APA/MLA Format Download EndNote Download BibTex|
Blood Proteins / analysis
Bronchial Hyperreactivity / physiopathology*
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid / chemistry
Cytokines / analysis
Eosinophil Granule Proteins
Eosinophilia / etiology, physiopathology
Genetic Complementation Test
Inflammation / physiopathology
Interleukin-10 / deficiency, genetics, physiology*
Leukotrienes / analysis
Lung / chemistry, pathology
Methacholine Chloride / administration & dosage, diagnostic use
Mice, Inbred C57BL
Muscle, Smooth / physiopathology
Ovalbumin / administration & dosage, immunology
Peroxidases / analysis
Respiratory Hypersensitivity / physiopathology*
Specific Pathogen-Free Organisms
Trachea / physiopathology
|HL-36577/HL/NHLBI NIH HHS; HL-61005/HL/NHLBI NIH HHS|
|0/Aerosols; 0/Blood Proteins; 0/Cytokines; 0/Eosinophil Granule Proteins; 0/Leukotrienes; 130068-27-8/Interleukin-10; 62-51-1/Methacholine Chloride; 9006-59-1/Ovalbumin; EC 1.11.1.-/Eosinophil Peroxidase; EC 1.11.1.-/Peroxidases; EC 3.1.-/Ribonucleases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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