| IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. | |
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MedLine Citation:
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PMID: 10811896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge. |
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Authors:
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M J Mäkelä; A Kanehiro; L Borish; A Dakhama; J Loader; A Joetham; Z Xing; M Jordana; G L Larsen; E W Gelfand |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 97 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-30 Completed Date: 2000-06-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6007-12 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Blood Proteins / analysis Bronchial Hyperreactivity / physiopathology* Bronchial Provocation Tests Bronchoalveolar Lavage Fluid / chemistry Cytokines / analysis Electric Stimulation Eosinophil Granule Proteins Eosinophil Peroxidase Eosinophilia / etiology, physiopathology Female Gene Therapy Genetic Complementation Test Immunization Inflammation / physiopathology Interleukin-10 / deficiency, genetics, physiology* Leukotrienes / analysis Lung / chemistry, pathology Male Methacholine Chloride / administration & dosage, diagnostic use Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth / physiopathology Ovalbumin / administration & dosage, immunology Peroxidases / analysis Respiratory Hypersensitivity / physiopathology* Ribonucleases* Specific Pathogen-Free Organisms Trachea / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-36577/HL/NHLBI NIH HHS; HL-61005/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Blood Proteins; 0/Cytokines; 0/Eosinophil Granule Proteins; 0/Leukotrienes; 130068-27-8/Interleukin-10; 62-51-1/Methacholine Chloride; 9006-59-1/Ovalbumin; EC 1.11.1.-/Eosinophil Peroxidase; EC 1.11.1.-/Peroxidases; EC 3.1.-/Ribonucleases |
| Comments/Corrections | |
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