Document Detail


IL-10 gene polymorphisms are associated with infectious cause of sudden infant death.
MedLine Citation:
PMID:  14630401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines are involved in regulating the intensity and duration of the immune response, and cytokine production is carefully regulated. With regard to sudden infant death, interleukin-10 (IL-10) is of special interest. This is an immunoregulatory cytokine that plays an important role in the development of infectious disease. The purpose of this study was to elucidate the relationship between polymorphisms in the promoter region of the IL-10 gene and sudden infant death due to either sudden infant death syndrome (SIDS) or infection. The polymorphisms investigated include the SNPs in base pairs (bp) -1082, -819, -592, and the two microsatellites IL-10G and IL-10R. The main finding is an association between the ATA haplotype and the ATA/ATA genotype and infectious death. The group of infectious deaths also had a higher percentage of the genotypes G21/G22 and G21/G23, compared with the SIDS patients. In addition, G21/G22 was found in a higher percentage of the SIDS patients than in the controls. These findings lead us to speculate that, in some situations, an infant with an unfavorable IL-10 genotype may exhibit aberrant IL-10 production, which in turn leads to an imbalance in the immune response and renders the infant unable to cope with the infection.
Authors:
Siri H Opdal; Anette Opstad; Ashild Vege; Torleiv O Rognum
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human immunology     Volume:  64     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1183-9     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Oslo, Rikshospitalet University Hospital, 0027 Oslo, Norway. s.h.opdal@labmed.uio.no
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MeSH Terms
Descriptor/Qualifier:
Cytokines / genetics,  immunology
Female
Genotype
Haplotypes / genetics*
Humans
Infant
Infection / complications,  genetics*,  immunology
Interleukin-10 / genetics*,  immunology
Male
Microsatellite Repeats / genetics
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics
Sudden Infant Death / etiology,  genetics*,  immunology
Chemical
Reg. No./Substance:
0/Cytokines; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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