Document Detail

Is the IL-10 Promoter Polymorphism at Position -592 Associated with Immune System-Related Diseases?
MedLine Citation:
PMID:  22886309     Owner:  NLM     Status:  Publisher    
Immune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL-10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.
Mojgan Noroozi Karimabad; Mohammad Kazemi Arababadi; Elham Hakimizadeh; Hassan Yousefi Daredori; Mahmood Nazari; Gholamhossein Hassanshahi; Derek Kennedy
Related Documents :
9475379 - Lactogenic hormone signal transduction.
20627699 - Breaking ranks: how leukocytes react to developmental cues and tissue injury.
11983149 - Wnt signaling and lymphocyte development.
16212919 - T lymphocyte co-signaling pathways of the b7-cd28 family.
24291709 - The human cathelicidin ll-37 enhances airway mucus production in chronic obstructive pu...
23434949 - Challenges in translational research on probiotic lactobacilli: from in vitro assays to...
20601459 - Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hyperchole...
7390619 - Induction of cell infiltration and acid hydrolase release into the peritoneal cavity of...
11787449 - How does stress affect you? an overview of stress, immunity, depression and disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-11
Journal Detail:
Title:  Inflammation     Volume:  -     ISSN:  1573-2576     ISO Abbreviation:  Inflammation     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Osteopenia/osteoporosis in patients with calcium nephrolithiasis.
Next Document:  Inflammatory Processes and Effects of Continuous Positive Airway Pressure (CPAP) in Overlap Syndrome...