| IL-1: discoveries, controversies and future directions. | |
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MedLine Citation:
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PMID: 20201008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although there has been a great amount of progress in the 25 years since the first reporting of the cDNA for IL-1alpha and IL-1beta, the history of IL-1 goes back to the early 1940s. In fact, the entire field of inflammatory cytokines, TLR and the innate immune response can be found in the story of IL-1. This Viewpoint follows the steps from the identification of the fever-inducing activities of "soluble factors" produced by endotoxin-stimulated leukocytes through to the discovery of cryopyrin and the caspase-1 inflammasome and on to the clinical benefits of anti-IL-1beta-based therapeutics. It also discusses some of the current controversies regarding the activation of the inflammasome. The future of novel anti-inflammatory agents to combat chronic inflammation is based, in part, on the diseases that are uniquely responsive to anti-IL-1beta, which is surely a reason to celebrate the 25th anniversary of the cloning of IL-1alpha and IL-1beta. |
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Authors:
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Charles A Dinarello |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 599-606 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. cdinarello@mac.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals History, 20th Century History, 21st Century Humans Inflammation / history*, immunology* Interleukin-1 / history*, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-15614/AI/NIAID NIH HHS; CA-04 6934/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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