| IL-1β Biological Treatment of Familial Mediterranean Fever. | |
| | |
MedLine Citation:
|
PMID: 23322405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Familial Mediterranean fever (FMF) is a recessive, autosomal, auto-inflammatory disorder characterised by brief, recurring, self-limited episodes of fever and serositis resulting in abdominal, chest, joint and muscular pain; it is the most common of the periodic hereditary fevers and mostly affects Mediterranean populations. Daily administration of colchicine, a tricyclic alkaloid with anti-microtubule and anti-inflammatory properties, prevents the recurrence of FMF attacks and the development of secondary (AA) amyloidosis, the major long-tem complication of FMF. Colchicine is generally safe and well-tolerated; nevertheless, 5-10 % of FMF patients do not respond to conventional treatment, while another 2-5 % of patients are colchicine-intolerant because of toxicity issues, leading physicians to search for alternative therapeutic strategies. Recent new insights into the mechanisms of auto-inflammation add further proof to the efficacy of IL-1 targeting drugs in colchicine non-responder/intolerant FMF patients. A systematic study of relevant literature through PubMed/Medline was performed in order to identify publications reporting IL-1β biological treatment of FMF. Treatment methods, comorbidities, clinical response and side effects in literature case reports were analysed, as well as recent advances in the pathogenesis of auto-inflammation mechanisms in FMF and the causes of colchicine resistance or toxicity in common clinical practice. The paradigmatic experience of an FMF patient with severe FMF mutations (M694V/M694V) suffering from colchicine toxicity and successfully treated with anakinra is also reported. The present data show that anti-IL-1β biological treatment is actually a therapeutic option for FMF patients unresponsive or intolerant to colchicine or in FMF patients with concomitant vasculitis. |
| | |
Authors:
|
Alessandra Soriano; Elena Verecchia; Antonella Afeltra; Raffaele Landolfi; Raffaele Manna |
Related Documents
:
|
9730155 - Patterns of care study of radiation therapy for cervix cancer in japan: the influence o... 3978645 - Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma an... 7575115 - Cystic neoplasms of the pancreas. a clinicopathologic study, including dna flow cytometry. 12168065 - Technetium-99m-tetrofosmin scintigraphy in patients with metastatic soft tissue sarcoma. 9063505 - Postmortem blood cultures. evaluation of separate sampling of blood from the right and ... 2906225 - Probable metachromatic leukodystrophy/pseudodeficiency compound heterozygote at the ary... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
|
Title: Clinical reviews in allergy & immunology Volume: - ISSN: 1559-0267 ISO Abbreviation: Clin Rev Allergy Immunol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Periodic Fever Research Centre-National Reference Centre for FMF, Catholic University of the Sacred Heart, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical Guidelines and Definitions of Autoinflammatory Diseases: Contrasts and Comparisons with Aut...
Next Document: STUB1 is essential for T-cell activation by ubiquitinating CARMA1.