Document Detail

IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea.
MedLine Citation:
PMID:  7690116     Owner:  NLM     Status:  MEDLINE    
Severe exercise in young females is a potent cause of menstrual irregularity, although the exact pathogenesis is currently unknown. We performed a cross-sectional endocrine and metabolic analysis of a group of elite athletes and dancers in order to establish which variable, if any, was specifically associated with changes in menstruation. By using a step-wise discriminant analysis, two independent predictors, elevated serum cortisol and insulin-like growth factor binding protein 1 (IGFBP-1) levels, were found to account for the majority (67%) of the variance. IGFBP-1 is a hepatic protein which is acutely and inversely regulated by insulin, and is thought to modulate the peripheral actions of IGF-1. While the change in serum cortisol may reflect activation of central stress pathways, these findings suggest for the first time that there is a second peripheral signal, IGFBP-1, which may relate the availability of metabolic fuels to the control of reproduction.
P J Jenkins; X Ibanez-Santos; J Holly; A Cotterill; L Perry; R Wolman; M Harries; A Grossman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroendocrinology     Volume:  57     ISSN:  0028-3835     ISO Abbreviation:  Neuroendocrinology     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-10-04     Completed Date:  1993-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  600-4     Citation Subset:  IM    
Department of Endocrinology, St. Bartholomew's Hospital, London, UK.
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MeSH Terms
Amenorrhea / blood*,  etiology
Carrier Proteins / blood*
Estradiol / blood
Follicle Stimulating Hormone / blood
Hydrocortisone / blood
Insulin-Like Growth Factor Binding Protein 1
Luteinizing Hormone / blood
Multivariate Analysis
Reg. No./Substance:
0/Carrier Proteins; 0/Insulin-Like Growth Factor Binding Protein 1; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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