| IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. | |
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MedLine Citation:
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PMID: 21457161 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sugita S, Morishita Y, Kano J, Furuya S, Shiba-Ishii A & Noguchi M (2011) Histopathology IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma Aims: To investigate the specific expression of insulin-like growth factor binding protein-1 (IGFBP-1) in ovarian clear cell adenocarcinoma (CCA). Methods and results: Immunohistochemistry and in situ hybridization for IGFBP-1 were performed in normal endometrium, placenta, and 100 surgically resected cases of ovarian cancer including 31 CCAs and 69 non-CCAs. Immunohistochemistry for hepatocyte nuclear factor-1 (HNF-1β) was also examined in all cases. Specific expression of IGFBP-1 was confirmed in secretory endometrium, decidua of placenta and Arias-Stella glands of miscarriage material. Among ovarian cancers, almost all cases of CCA showed expression of both IGFBP-1 protein and mRNA, but non-CCA hardly expressed IGFBP-1. There was a significant difference between CCA and non-CCA in the expression of IGFBP-1 protein and mRNA. No correlation was found between the rate of IGFBP-1 expression and pathological T and N factors of the tumour-node-metastasis (TNM) classification. All CCA cases except for one exhibited expression of HNF-1β protein, whereas only 15.9% of non-CCAs did so. Conclusion: The expression of IGFBP-1 in CCA is more specific than that of HNF-1β. IGFBP-1 shows expression by decidual endometrium and Arias-Stella glands, and CCA also exhibits characteristic expression. These results indicate that IGFBP-1 is a immunohistochemical marker for CCA. |
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Authors:
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Shintaro Sugita; Yukio Morishita; Junko Kano; Shuichiro Furuya; Aya Shiba-Ishii; Masayuki Noguchi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-4 |
Journal Detail:
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Title: Histopathology Volume: - ISSN: 1365-2559 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Limited. |
Affiliation:
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Department of Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba Department of Pathology, Tsukuba University Hospital, Amakubo, Tsukuba, Ibaraki, Japan. |
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