Document Detail


IGF2 genotype and obesity in men and women across the adult age span.
MedLine Citation:
PMID:  12075589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied a previously reported association between the IGF2 gene's ApaI polymorphism and obesity in 500 healthy men and women (19-90 y). We hypothesized that individuals homozygous for the IGF2 A allele (A/A) would exhibit lower body mass, BMI and DEXA-measured fat mass compared to G/G homozygotes. Subjects were categorized as exhibiting the G/G (n = 241), G/A (n = 197) or A/A (n = 62) genotype. Contrary to our hypothesis, no difference was observed in body mass, body mass index (BMI) or fat mass between the G/G and A/A genotype groups in the entire cohort. Surprisingly, Caucasian A/A individuals (n = 427) exhibited significantly higher fat mass compared to Caucasian G/G individuals (P < 0.05). In summary, individuals homozygous for the IGF2 G allele do not exhibit higher body mass, BMI or fat mass compared to A/A individuals; however, Caucasians with the A/A genotype exhibit higher fat mass than G/G individuals.
Authors:
S M Roth; M A Schrager; E J Metter; S E Riechman; J L Fleg; B F Hurley; R E Ferrell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  26     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-21     Completed Date:  2002-07-19     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  585-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue
Adult
Aged
Aged, 80 and over
Alleles
Body Composition
Body Mass Index
Female
Genotype
Homozygote
Humans
Insulin-Like Growth Factor II / analysis,  genetics*
Longitudinal Studies
Male
Middle Aged
Obesity / epidemiology*,  genetics*
Grant Support
ID/Acronym/Agency:
AG-05893/AG/NIA NIH HHS; AG-16205/AG/NIA NIH HHS; DK-46204/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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