| The IGF system after insertion of a transjugular intrahepatic porto-systemic shunt in patients with liver cirrhosis. | |
MedLine Citation:
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PMID: 19336524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Insertion of a transjugular intrahepatic porto-systemic shunt (TIPS) into patients with liver cirrhosis usually induces a gain in body cell mass. Changes in the IGF system in favor of anabolism may be involved. We, therefore measured blood concentrations of the components of the IGF system in cirrhosis patients before and after elective TIPS. DESIGN AND METHODS: The study comprised 17 patients and 11 healthy controls. Patients were examined before and 1, 4, 12, and 52 weeks after TIPS. Biochemical analyses of the IGF system were compared with changes in body composition (bioimpedance analysis), glucose and insulin, and metabolic liver function (galactose elimination capacity). RESULTS: After TIPS, body cell mass rose by 3.2 kg (95% confidence interval (CI): 1.0-5.5) at 52 weeks, in correlation with baseline liver function (r(2)=0.22; P=0.03). Peripheral blood concentrations of total IGF1 and 2, bioactive IGF1, and the IGF-binding proteins (IGFBP-1, -2, and -3) remained unchanged throughout the study period. There was no change in fasting glucose, whereas fasting insulin rose by 40% (CI: 11-77%) and glucagon by 58% (CI: 11-132%) from baseline to 52 weeks after TIPS. CONCLUSION: Our data confirm that TIPS was associated with an increase in body cell mass in patients with liver cirrhosis, but without any change in the circulating IGF system. Thus, the results do not support the notion that effects on the circulating IGF system are involved in the anabolic effects of TIPS insertion. |
Authors:
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Peter Holland-Fischer; Hendrik Vilstrup; Jan Frystyk; Dennis Tønner Nielsen; Allan Flyvbjerg; Henning Grønbaek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-31 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 160 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 957-63 Citation Subset: IM |
Affiliation:
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Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark. phf@svf.au.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis Body Composition Dietary Proteins / metabolism Energy Intake Female Humans Insulin-Like Growth Factor Binding Proteins / blood* Liver / metabolism Liver Cirrhosis / blood, metabolism*, surgery* Male Middle Aged Portasystemic Shunt, Transjugular Intrahepatic / adverse effects* Somatomedins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Proteins; 0/Insulin-Like Growth Factor Binding Proteins; 0/Somatomedins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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