| IGF-I polymorphism is associated with lean mass, exercise economy, and exercise performance among premenopausal women. | |
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MedLine Citation:
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PMID: 17174724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We undertook this study to investigate the association of a genetic polymorphism of the insulin-like growth factor, IGF-I(189), on body composition, exercise performance and exercise economy, after controlling for the independent effect of race as assessed by African genetic admixture (AFADM). METHODS: A total of 114 premenopausal sedentary women were genotyped for IGF-I189, obtaining measures of fat mass, lean body mass, VO2 during cycling and stairclimbing, time on treadmill and leg strength. A quantitative value for AFADM was derived from genotypic information of approximately 40 ancestry informative markers and used as covariate in statistical models. RESULTS: After adjusting for AFADM, IGF-I189 was negatively associated with lean body mass (p = 0.029) and lean leg mass (p = 0.050). Leg strength was not associated with the presence/absence of IGF-I189 (p = 0.380), but carriers of the allele demonstrated a longer time on the treadmill (p = 0.015) after adjusting for AFADM. There was also a negative relationship between oxygen uptake during cycling and presence of the IGF-I189 independent of AFADM (p = 0.010). CONCLUSIONS: Independent of AFADM, individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance. |
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Authors:
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Mardya López-Alarcón; Gary R Hunter; Barbara A Gower; José R Fernández |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-03 |
Journal Detail:
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Title: Archives of medical research Volume: 38 ISSN: 0188-4409 ISO Abbreviation: Arch. Med. Res. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-18 Completed Date: 2007-02-20 Revised Date: 2011-09-02 |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 56-63 Citation Subset: IM |
Affiliation:
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Medical Nutrition Research Unit, Pediatric Hospital, Siglo XXI, National Medical Center, Mexico City, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans / genetics Body Composition / genetics* European Continental Ancestry Group / genetics Exercise Female Humans Insulin-Like Growth Factor I / genetics* Leg / anatomy & histology Middle Aged Organ Size Oxygen Consumption / genetics Physical Fitness* Polymorphism, Genetic* Premenopause |
| Grant Support | |
ID/Acronym/Agency:
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M01RR00032/RR/NCRR NIH HHS; P30 DK056336-05/DK/NIDDK NIH HHS; P30DK56336/DK/NIDDK NIH HHS; R01DK 51684/DK/NIDDK NIH HHS; R01DK-49779/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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