Document Detail


IGF-I and IGF binding proteins in diabetes-related kidney growth.
MedLine Citation:
PMID:  1283098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The kidney is a site of insulin-like growth factor I (IGF-I) production and IGF-I mediates effects on kidney growth and function. Diabetes is associated with kidney growth in man and the rat and, in the latter, commences within 48 h of induction of diabetes. Levels of kidney IGF-I are increased during the first 2-3 days of diabetes and this is at least partially due to increased production. Additionally, IGF-I binding is increased in diabetic rat kidney, due to increased binding to the IGF-I receptor and induction of proximal tubular binding protein expression. These changes are attenuated in prepubertal rats suggesting hormonal regulation. Further studies suggest that the changes are partly GH-dependent but independent of direct sex steroid effects. As kidney growth has been implicated in the subsequent development of diabetic nephropathy, further exploration of the close association between diabetes-related kidney growth and IGF-I accumulation may lead to an improved understanding of this complication.
Authors:
L A Bach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Growth regulation     Volume:  2     ISSN:  0956-523X     ISO Abbreviation:  Growth Regul.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106990     Medline TA:  Growth Regul     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  30-9     Citation Subset:  IM    
Affiliation:
Endocrine Unit, Austin Hospital, Heidelberg, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / physiology*
Cell Division / physiology
Diabetes Mellitus / pathology,  physiopathology*
Diabetic Nephropathies / physiopathology
Humans
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I / physiology*
Kidney / growth & development*,  pathology,  physiology
Rats
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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