Document Detail


IGF-binding protein-5 stimulates osteoblast activity and bone accretion in ovariectomized mice.
MedLine Citation:
PMID:  11440904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin-like growth factor binding protein-5 (IGFBP-5) is an osteoblast secretory protein that becomes incorporated into the mineralized bone matrix. In osteoblast cultures, IGFBP-5 stimulates cell proliferation by an IGF-independent mechanism. To evaluate whether IGFBP-5 can stimulate osteoblast activity and enhance bone accretion in a mouse model of osteoblast insufficiency, daily subcutaneous injections of either intact [IGFBP-5 (intact)] or carboxy-truncated IGFBP-5 [IGFBP-5-(1--169)] were given to ovariectomized (OVX) mice for 8 wk. Femur and spine bone mineral density (BMD), measured every 2 wk, showed early and sustained increases in response to IGFBP-5. Bone histomorphometry of cancellous bone showed significant elevations in the bone formation rate in both the femur metaphysis [IGFBP-5- (1)] only) and spine compared with OVX controls. IGFBP-5 also stimulated osteoblast number in the femur IGFBP-5-(1--169) only) and spine. These data indicate that IGFBP-5 effectively enhances bone formation and bone accretion in OVX mice by stimulating osteoblast activity. The finding that IGFBP-5-(1--169) is bioactive in vivo indicates that the carboxy-terminal portion is not required for this bone anabolic effect.
Authors:
D L Andress
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  281     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-06     Completed Date:  2001-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E283-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Washington, Seattle 98105, USA. dandress@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Density / drug effects*
Cell Count
Estrogens / deficiency
Female
Femur / cytology,  drug effects
Injections, Subcutaneous
Insulin-Like Growth Factor Binding Protein 5 / administration & dosage*,  analogs & derivatives
Mice
Mice, Inbred C3H
Osteoblasts / cytology,  drug effects*
Ovariectomy
Spine / cytology,  drug effects
Grant Support
ID/Acronym/Agency:
R01 AR-44911/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Insulin-Like Growth Factor Binding Protein 5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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