Document Detail

IGF-binding protein-2 is induced during development of urinary bladder hypertrophy in the diabetic rat.
MedLine Citation:
PMID:  9124338     Owner:  NLM     Status:  MEDLINE    
Because the locally produced insulin-like growth factor-binding proteins (IGFBP) may influence bladder hypertrophy, either directly or by their interaction with insulin-like growth factor I (IGF-I), we studied the IGF system during the development of urinary bladder hypertrophy in rats with streptozotocin-induced diabetes. Messenger RNA for IGF-I, IGFBP-2, and IGFBP-4 was determined by solution hybridization. The bladder wet weight was elevated after 7 days. DNA synthesis was increased and peaked at 2 days, whereas DNA content per bladder wet weight was decreased by 7 days. The IGF-I mRNA did not change during the first 7 days and then decreased, and IGFBP-4 mRNA was increased transiently on day 7. On the other hand, IGFBP-2 mRNA was significantly increased after 1 day (2-fold), peaked by 7 days (6.4-fold), and then declined to approximately 50% above control at the end of experiment. This was associated with an increased IGFBP-2 protein content. Our results suggest that both stretching of the bladder due to diuresis and the diabetic state contribute to changes of the IGF system in the hypertrophying bladder.
Y Chen; B Gustafsson; H J Arnqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E297-303     Citation Subset:  IM    
Department of Cellbiology, Faculty of Health Sciences, University of Linköping and University Hospital, Sweden.
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MeSH Terms
DNA / metabolism
Diabetes Mellitus, Experimental / metabolism*,  pathology*
Insulin-Like Growth Factor Binding Protein 2 / genetics,  metabolism*
Insulin-Like Growth Factor Binding Protein 4 / genetics,  metabolism
Insulin-Like Growth Factor I / genetics,  metabolism
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Urinary Bladder / metabolism*,  pathology*
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 4; 0/RNA, Messenger; 67763-96-6/Insulin-Like Growth Factor I; 9007-49-2/DNA

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