Document Detail


IGF-I Measurement Across Blood, Interstitial Fluid, and Muscle Biocompartments Following Explosive, High Power Exercise.
MedLine Citation:
PMID:  22933025     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
IGF-I resides across different biocompartments (blood, interstitial fluid (ISF) and muscle). Whether circulating IGF-I responses to exercise reflect local events remains uncertain. We measured the IGF-I response to plyometric exercise across blood, ISF, and muscle biopsy from the vastus lateralis. 20 volunteers (8 men, 12 women, 22±1 yr) performed 10 sets of 10 plyometric jump repetitions at a 40% 1-Repetition Maximum. Blood, ISF, and muscle samples were taken pre- and post- exercise. Circulating IGF-I increased post-exercise: Total IGF-I (pre = 546 ± 42, mid = 585 ± 43, post = 597 ± 45, + 30 = 557 ± 42, + 60 = 536 ± 40, +120 = 567 ± 42 ng/ml; mid, post and +120 greater than pre, P < 0.05); Free IGF-I (pre = 0.83 ± 0.09, mid = 0.78 ± 0.10, post = 0.79 ± 0.11, +30 = 0.93 ± 0.10, +60 = 0.88 ± 0.10, + 120 = 0.91 ± 0.11 ng/ml; +30 greater than all other preceding time points, P < 0.05). No exercise-induced changes were observed for ISF IGF-I (pre = 2.35 ± 0.29, post = 2.46 ± 0.35 ng/mL). No changes were observed for skeletal muscle IGF-I protein, although IGF-I mRNA content increased ~40% post-exercise. The increase in circulating total and free IGF-I was not correlated with increases in ISF IGF-I or muscle IGF-I protein content. Our data indicate that exercise-induced increases in circulating IGF-I are not reflective of local IGF-I signaling.
Authors:
Bradley C Nindl; Maria L Urso; Joseph R Pierce; Dennis Edward Scofield; Brian R Barnes; William J Kraemer; Jeffrey M Anderson; Carl M Maresh; Kathleen N Beasley; Edward J Zambraski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-29
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1United States Army Research Institute of Environmental Medicine.
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