| IGF-I, IGF-IR and IRS1 expression as an early reaction of PDL cells to experimental tooth movement in the rat. | |
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MedLine Citation:
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PMID: 20116783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize in vivo the role of IGF-I and its signalling, as an early reaction in the mechanotransduction process and to analyse changes of the local expression related to the magnitude of the applied force. MATERIALS AND METHODS: Forces of 0.1N, 0.25 N and 0.5 N were applied to move the right upper first molars of 12 anaesthetized rats mesially. These forces were kept constant for 4h. The untreated contralateral side served as a control. Paraffin-embedded sections of the resected jaws were prepared for immunohistochemistry to localize insulin-like growth factor-I (IGF-I), its receptor (IGF-IR), and insulin receptor substrate 1 (IRS1). Histomorphometric analysis was performed to count the percentage of immunoreactive cells in different parts of the periodontal ligament. RESULTS: IGF-I, IGF-IR and IRS1 positive cells were observed in the periodontal tissues of the control and loaded teeth. In the experimental group, the number of IGF-I-, IGF-IR- and IRS1-positive cells increased significantly on the tension side and decreased on the compression side. CONCLUSIONS: These data indicate a close relationship between mechanical loading of the PDL and the autocrine/paracrine expression of IGF components as an early step in the mechanotransduction process leading in the long term to an organized remodelling of the alveolar bone. |
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Authors:
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Yasser Kheralla; Werner G?tz; Afshar Kawarizadeh; B Rath-Deschner; Andreas J?ger |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-08 |
Journal Detail:
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Title: Archives of oral biology Volume: 55 ISSN: 1879-1506 ISO Abbreviation: Arch. Oral Biol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0116711 Medline TA: Arch Oral Biol Country: England |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: D; IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Orthodontics, Dental Clinic, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany. Yasser.kheralla@ukb.uni-bonn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolar Process
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cytology Animals Biomechanics Dental Cementum / cytology Fibroblasts / cytology Insulin Receptor Substrate Proteins / analysis* Insulin-Like Growth Factor I / analysis* Male Mechanotransduction, Cellular / physiology Molar / physiology Orthodontic Wires Osteoblasts / cytology Osteoclasts / cytology Periodontal Ligament / cytology* Pressure Rats Rats, Wistar Receptor, IGF Type 1 / analysis* Stress, Mechanical Time Factors Tooth Movement* Torque Transducers |
| Chemical | |
Reg. No./Substance:
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0/Insulin Receptor Substrate Proteins; 0/Irs1 protein, rat; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1 |
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