Document Detail


IGF-I, IGF-II, IGFBP2, IGFBP3 and acid-labile subunit (ALS) in colorectal cancer patients before surgery and during one year follow up in relation to age.
MedLine Citation:
PMID:  19482725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the changes of IGF system in colon cancer patients in relation to age, the serum IGF-I, IGF-II, IGFBP2, IGFBP3 and ALS were measured by immunochemistry before surgery, as well as one and six months after surgery. MATERIAL AND METHODS: One hundred and twenty six patients were included into the study: group I (<50 yrs, N=21); group II (50 to <55 yrs, N=16) ; group III (55 to <65 yrs, N=34); group IV (65 to <75 yrs, N=42) and group V (> or =75 yrs, N=13). RESULTS: Before surgery: only the mean value of IGF-I concentration in group I was significantly higher as compared to group V (p<0.01). One month after surgery: 1) a decrease in the mean values of IGF-I, IGF-II, IGFBP3 and ALS levels was observed, but only for IGF-II (groups II-V), IGFBP3 (groups II-V) and ALS (groups III-V) the changes were significant; 2) the mean value of ALS level in group I was higher as compared to group III-V (p<0.05 to 0.02); 3) higher mean values of IGF-I/alb, IGFBP3/alb and ALS/alb were noted for group I as compared to group V (p<0.01 to 0.001); 4) the mean levels of IGFBP2 were significantly lower in group I as compared to groups II, III, IV and V (p<0.001 in all cases). CONCLUSIONS: In colon cancer patients IGF-I, IGFBP3 and ALS decrease with age, but the relation between them exists regardless the patient's age and time of observation. Lower IGFBP2 level together with higher IGF-I might contribute to more aggressive course of disease in colon cancer patients below 50 years of age.
Authors:
K Sztefko; D Hodorowicz-Zaniewska; T Popiela; P Richter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in medical sciences     Volume:  54     ISSN:  1898-4002     ISO Abbreviation:  Adv Med Sci     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-03     Completed Date:  2010-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276222     Medline TA:  Adv Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Paediatric Institute, Jagiellonian University, Krakow, Poland. misztefk@cyf-kr.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging
Analysis of Variance
Carrier Proteins / blood*
Colorectal Neoplasms / blood*,  surgery
Disease Progression
Female
Follow-Up Studies
Glycoproteins / blood*
Humans
Insulin-Like Growth Factor Binding Protein 2 / blood*
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / analysis*
Insulin-Like Growth Factor II / analysis*
Male
Middle Aged
Risk Factors
Time Factors
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Glycoproteins; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/insulin-like growth factor binding protein, acid labile subunit; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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