Document Detail

IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice.
MedLine Citation:
PMID:  20014946     Owner:  NLM     Status:  MEDLINE    
Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-bromo-2-deoxyuridine labeling following chemotherapy given to C57BL/6 mice revealed a similar reduction in neural cell proliferation in the dentate gyrus for all four agents. Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation.
Michelle C Janelsins; Joseph A Roscoe; Michel J Berg; Bryan D Thompson; Mark J Gallagher; Gary R Morrow; Charles E Heckler; Pascal Jean-Pierre; Lisa A Opanashuk; Robert A Gross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-05-14     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  544-53     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / metabolism,  toxicity*
Blood-Brain Barrier*
Bromodeoxyuridine / metabolism
Cell Proliferation / drug effects
Cyclophosphamide / toxicity
Dentate Gyrus / drug effects*
Doxorubicin / toxicity
Fluorouracil / toxicity
Insulin-Like Growth Factor I / pharmacology*
Mice, Inbred C57BL
Neurogenesis / drug effects
Neurons / drug effects
Paclitaxel / toxicity
Weight Loss
Grant Support
R25 CA102618/CA/NCI NIH HHS; R25 CA102618-06A1/CA/NCI NIH HHS; R25CA01618/CA/NCI NIH HHS; U10 CA037420/CA/NCI NIH HHS
Reg. No./Substance:
0/Antineoplastic Agents; 33069-62-4/Paclitaxel; 67763-96-6/Insulin-Like Growth Factor I; 80168379AG/Doxorubicin; 8N3DW7272P/Cyclophosphamide; G34N38R2N1/Bromodeoxyuridine; U3P01618RT/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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