Document Detail


IFPA Trophoblast Research Award Lecture: the dynamic role of Bcl-2 family members in trophoblast cell fate.
MedLine Citation:
PMID:  19095301     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bcl-2 family members are important regulators of cell fate in normal organ development and in disease status. Pro- and anti-apoptotic members of this family function through a complex network of homo- and hetero-dimers to determine whether a cell lives or dies. Members of the Bcl-2 family are classically recognized for their role in apoptosis, yet emerging evidence has highlighted their importance in the regulation of cell cycle. Cellular proliferation, differentiation and death accompany early placental development of the trophoblast lineage. We have recently reported on the expression and function of two Bcl-2 family members in normal placental development, namely the pro-apoptotic Mtd/Bok, and its anti-apoptotic partner Mcl-1 and have found that their expression is upregulated by low oxygen, a key mediator of trophoblast cell proliferation in early placentation. Interestingly, we have also reported that the expression of the Mtd/Mcl-1 system is altered in preeclampsia, a placental pathology associated with a status of oxidative stress and typically characterized by an immature proliferative trophoblast phenotype and excessive trophoblast cell death. In this pathology levels of pro-apototic Mtd-L and Mtd-P are increased and anti-apoptotic Mcl-1 is cleaved in to a pro-apoptotic isoform. Disruption in Mtd/Mcl-1 expression seen in preeclampsia may contribute to both the increased apoptosis and hyperproliferative nature of this disorder.
Authors:
J Ray; A Jurisicova; I Caniggia
Publication Detail:
Type:  Lectures; Research Support, Non-U.S. Gov't     Date:  2008-12-17
Journal Detail:
Title:  Placenta     Volume:  30 Suppl A     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S96-100     Citation Subset:  IM    
Affiliation:
Department of Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada. ray@lunenfeld.ca
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / physiology
Awards and Prizes
Female
Humans
Placentation / physiology*
Pre-Eclampsia / physiopathology
Pregnancy
Proto-Oncogene Proteins c-bcl-2 / physiology*
Trophoblasts / metabolism*
Chemical
Reg. No./Substance:
0/BOK protein, human; 0/Proto-Oncogene Proteins c-bcl-2; 0/myeloid cell leukemia sequence 1 protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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