Document Detail

IFPA Senior Award Lecture: Reproductive immunology in perspective--reprogramming at the maternal-fetal interface.
MedLine Citation:
PMID:  23294570     Owner:  NLM     Status:  MEDLINE    
Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cells in mammalian uteri are reprogrammed, losing their cytotoxic potential and providing an immunosuppressive environment suitable for harboring the genetically different fetus. We propose that it is the placenta that is mainly responsible for this conversion and maintenance throughout pregnancy. Studies in our laboratory indicate that trophoblast-derived soluble HLA-G has a subtle but well defined role in programming uterine placental macrophages, a potentially destructive immune cell population. Thus, placental HLA-G plays a critical role in assuring that the developing fetus emerges unscathed at parturition.
J S Hunt; M G Petroff
Publication Detail:
Type:  Lectures; Research Support, N.I.H., Extramural     Date:  2013-01-05
Journal Detail:
Title:  Placenta     Volume:  34 Suppl     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2014-03-12     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S52-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Awards and Prizes
Fetal Development / immunology*
HLA-G Antigens / physiology
Immune Tolerance / genetics,  immunology
Immunity, Innate / physiology
Maternal-Fetal Exchange / immunology*
Reproduction / immunology*
Grant Support
P01 HD049480/HD/NICHD NIH HHS; P01049480//PHS HHS; R01 HD 045611/HD/NICHD NIH HHS; R01 HD045611/HD/NICHD NIH HHS
Reg. No./Substance:
0/HLA-G Antigens

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