Document Detail


IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review.
MedLine Citation:
PMID:  16442615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrauterine growth restriction is associated with a range of alterations in placental transport functions: the activity of a number of transporters is reduced (Systems A, L and Tau, transporters for cationic amino acids, the sodium-proton exchanger and the sodium pump), placental glucose transporter activity and expression are unchanged whereas the activity of the calcium pump is increased. In contrast, accelerated fetal growth in association to diabetes is characterized by increased activity of placental Systems A and L and glucose transporters. Evidence suggests that these placental transport alterations are the result of specific regulation and that they, at least in part, contribute to the development of pathological fetal growth rather than representing a consequence to altered fetal growth. One interpretation of this data is that the placenta functions as a nutrient sensor, altering placental transport functions according to the ability of the maternal supply line to provide nutrients. Placental transporters are subjected to regulation by hormones. Insulin up-regulates several key placental transporters and maternal insulin may represent a "good nutrition" signal to increase placental nutrient transfer and the growth of the fetus. Preliminary evidence suggests that placental mammalian target of rapamycin, a protein kinase regulating protein translation and transcription in response to nutrient stimuli, may be involved in placental nutrient sensing.
Authors:
T Jansson; T L Powell
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Publication Detail:
Type:  Lectures     Date:  2006-01-25
Journal Detail:
Title:  Placenta     Volume:  27 Suppl A     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S91-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267, USA. Thomas.jansson@uc.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport Systems / metabolism
Awards and Prizes
Biological Transport
Female
Fetal Development*
Fetal Growth Retardation / etiology,  metabolism*,  physiopathology
Gene Expression Regulation, Developmental
Humans
Ion Transport
Placenta / blood supply,  physiology*
Placental Circulation
Pregnancy
Societies, Scientific
Chemical
Reg. No./Substance:
0/Amino Acid Transport Systems

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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