| IFN-α in the Treatment of Melanoma. | |
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MedLine Citation:
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PMID: 23042723 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Among the IFNs, IFN-α2 has been the most broadly evaluated clinically. At the molecular level, IFN-α has multiple effects in a variety of malignancies that range from antiangiogenic to potent immunoregulatory, differentiation-inducing, antiproliferative, and proapoptotic effects. A multitude of IFN-α2 regimens that may be classified as low dose, intermediate dose, and high dose have been evaluated as adjuvant therapy in melanoma. A durable impact on both relapse-free and overall survival was seen only with the regimen utilizing high-dose IFN-α2b tested in the Eastern Cooperative Oncology Group and intergroup trials E1684, E1690, and E1694 as adjuvant therapy for high-risk surgically resected melanoma (stage IIB or III). Adjuvant pegylated IFN-α2b has also been evaluated at maximally tolerable doses compared with the observation group in the European Organization for Research and Treatment of Cancer trial 18991 and has shown relapse-free survival benefits in patients with microscopic nodal disease. |
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Authors:
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Ahmad A Tarhini; Helen Gogas; John M Kirkwood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 189 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 3789-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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