| IFN-gamma reduction by tricyclic antidepressants. | |
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MedLine Citation:
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PMID: 21391412 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: A growing body of data indicates that an activation of proinflammatory cytokines such as interferon-gamma (IFN-gamma) is involved in the pathophysiology of depression and that the suppression of pro-inflammatory cytokine production by antidepressants may lead to an improvement of depressive symptoms. However, the influence of the serotonin and noradrenalin reuptake inhibitor (SNRI) venlafaxine and its metabolite O-desmethylvenlafaxine on the stimulated blood cell secretion of IFN-gamma has not been studied so far. METHOD: We measured IFN-gamma levels in the stimulated blood of healthy female subjects in a whole blood assay using the toxic shock syndrome toxin TSST-1 as stimulant. Blood was either supplemented with antidepressants or not. RESULTS: Mean IFN-gamma concentrations differed between blood with and without antidepressant supplements (p = 0.026). Planned contrasts revealed that compared to non-supplemented blood, four of the blood samples supplemented with the tricyclic antidepressants (TCAs) reduced IFN-gamma levels: amitriptyline (adjusted p-value (p = 0.004), nortriptyline (p = 0.037), imipramine (p = 0.021), and desipramine (p = 0.048). There was no significant difference between the control condition and the venlafaxine or O-desmethylvenlafaxine condition. CONCLUSIONS: TCAs might, among other mechanisms, act as antidepressants by suppressing the production of pro-inflammatory cytokines, whereas no significant effect of venlafaxine and O-desmethylvenlafaxine on IFN-gamma secretion could be demonstrated. |
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Authors:
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Hubertus Himmerich; Stephany Fulda; Abigail J Sheldrick; Birgit Plümäkers; Lothar Rink |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of psychiatry in medicine Volume: 40 ISSN: 0091-2174 ISO Abbreviation: Int J Psychiatry Med Publication Date: 2010 |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365646 Medline TA: Int J Psychiatry Med Country: United States |
Other Details:
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Languages: eng Pagination: 413-24 Citation Subset: IM |
Affiliation:
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Aachen University, Germany. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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