Document Detail


IFN-gamma plays a dominant role in upregulation of Candida-specific IgE synthesis in patients with atopic dermatitis.
MedLine Citation:
PMID:  10899763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although Candida albicans (CA) is known to induce Th1 clones that suppress IgE synthesis, serum IgE antibody against CA is often increased in atopic patients. This study aims to elucidate the mechanism of IgE synthesis against CA in atopic patients. METHODS: We measured the production of IL-4 and IFN-gamma by peripheral blood mononuclear cells (PBMCs) from atopic patients upon stimulation with CA and examined the correlation with the level of serum IgE antibody against CA. Results: The level of serum CA-specific IgE antibody (CA-IgE) was significantly higher in patients with atopic dermatitis (AD) than in patients with bronchial asthma (BA) (geometric mean = 3.6 vs. 0.27 U(A)/ml, p < 0.02) (U(A) = unit allergen), while there was no difference in the level of house dust mite-specific IgE antibody between them (67.6 vs. 87.1 U(A)/ml). Although IL-4 production by PBMCs upon stimulation with CA in patients with AD was not significantly different from that in patients with BA (mean = 359.1 vs. 515.3 fg/ml), IFN-gamma production was significantly lower in the former than in the latter group (8.1 vs. 56.2 pg/ml, p < 0.001). Consequently, the ratio of IL-4/IFN-gamma production was apparently higher in patients with AD than in those with BA, which corresponds to the difference between them in the level of serum CA-IgE. A significant negative correlation was seen in patients with AD between IFN-gamma production by CA-stimulated PBMCs and the level of serum CA-IgE (p < 0.05). CONCLUSIONS: IgE synthesis against CA in atopic patients may be precipitated not by enhancing IL-4 production, but by reducing IFN-gamma secretion.
Authors:
M Kimura; S Tsuruta; T Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  122     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-05     Completed Date:  2000-09-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Affiliation:
Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital, Shizuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Fungal / biosynthesis
Candida / immunology*
Child
Child, Preschool
Dermatitis, Atopic / immunology*,  microbiology
Female
Humans
Immunoglobulin E / biosynthesis*
Interferon-gamma / biosynthesis,  physiology*
Interleukin-4 / biosynthesis
Leukocytes, Mononuclear / drug effects,  metabolism
Male
Up-Regulation*
Chemical
Reg. No./Substance:
0/Antibodies, Fungal; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E; 82115-62-6/Interferon-gamma

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