| IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population. | |
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MedLine Citation:
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PMID: 22053898 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The evaluation of susceptibility loci is an important addition to the current predictive and screening models in type 1 diabetes of Chinese Han population. Therefore, the aim of this study is to provide evidence for the association between type 1 diabetes and two polymorphisms (rs3747517, rs1990760) from interferon induced with helicase C domain 1 (IFIH1). Here, 464 Type 1 diabetes patients and 465 control subjects were genotyped for these 2 polymorphisms. The results indicated that the allelic frequencies of rs3747517 revealed a strong association with type 1 diabetes risk (P <0.001); yet, no significant association was observed on rs1990760 (P =0.76). Furthermore, IFIH1 rs3747517 polymorphism had no influence on the positive rates of pancreatic auto-antibodies, and both of the polymorphisms had no interaction with HLA class-linked is this class-linked? risk or phenotypes. In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population. |
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Authors:
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Hui Yang; Kuanfeng Xu; Rong Gu; Heng Chen; Dan Yu; Chunyan Xing; Yu Liu; Liping Yu; John Hutton; George Eisenbarth; Tao Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-4 |
Journal Detail:
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Title: Autoimmunity Volume: - ISSN: 1607-842X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology, The First Affiliated Hospital, Nanjing Medical University , Nanjing , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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