Document Detail


IDRD2 TaqIA polymorphism is associated with urinary homovanillic acid levels in a sample of Spanish male alcoholic patients.
MedLine Citation:
PMID:  15545020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the DRD2 genotype of the TaqIA1 allele in Spanish alcoholics is associated with higher levels of urine homovanillic acid (HVA) when compared to patients homozygous for the TaqIA2 allele. A sample of 142 Spanish male alcoholic patients was split into 2 groups on the basis of the presence or absence of the A1 allele in their genotype. The urine sample was analyzed by high performance liquid cromatography (HPLC), and the concentration of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and vanilylmandelic acid (VMA) was determined. We found a statistical difference in the concentration of HVA between the groups, that suggests this polymorphism could be related to the variance of urine HVA levels.
Authors:
G Ponce; J Hoenicka; R Rodríguez-Jiménez; A Gozalo; M Jimenéz; R Monasor; M Aragüés; G Rubio; M A Jiménez-Arriero; J A Ramos; T Palomo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicity research     Volume:  6     ISSN:  1029-8428     ISO Abbreviation:  Neurotox Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-16     Completed Date:  2005-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100929017     Medline TA:  Neurotox Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-7     Citation Subset:  IM    
Affiliation:
Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n. 28041 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alcoholism / epidemiology,  genetics*,  urine*
Alleles
Biogenic Monoamines / urine
Chromatography, High Pressure Liquid
Gene Frequency
Genotype
Homovanillic Acid / urine*
Humans
Male
Middle Aged
Polymorphism, Genetic / genetics*
Receptors, Dopamine D2 / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Spain / epidemiology
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 0/Receptors, Dopamine D2; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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