| IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease. | |
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MedLine Citation:
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PMID: 22084593 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. IDO activity has been shown to reflect the extent and the course in a plethora of malignancies including prostate, colorectal, pancreatic, cervical, endometrial, gastric, lung, bladder, ovarian, esophageal and renal cell carcinomas, glioblastomas, mesotheliomas, and melanomas. Furthermore IDO activity during malignant tumor diseases seems to be part of the tumoricidal immune defense strategy, which in the long run is detrimental to the host, when tryptophan deprivation and production of pro-apoptotic tryptophan catabolites counteract T-cell responsiveness. |
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Authors:
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Robert Sucher; Katharina Kurz; Guenter Weiss; Raimund Margreiter; Dietmar Fuchs; Gerald Brandacher |
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Publication Detail:
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Type: Journal Article Date: 2010-06-10 |
Journal Detail:
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Title: International journal of tryptophan research : IJTR Volume: 3 ISSN: 1178-6469 ISO Abbreviation: Int J Tryptophan Res Publication Date: 2010 |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101513378 Medline TA: Int J Tryptophan Res Country: New Zealand |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: - |
Affiliation:
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Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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