Document Detail


IDH1 and IDH2 mutations in gliomas.
MedLine Citation:
PMID:  23532369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade gliomas and secondary high-grade gliomas. These mutations, which occur early in gliomagenesis, change the function of the enzymes, causing them to produce 2-hydroxyglutarate, a possible oncometabolite, and to not produce NADPH. IDH mutations are oncogenic, although whether the mechanism is through alterations in hydroxylases, redox potential, cellular metabolism, or gene expression is not clear. The mutations also drive increased methylation in gliomas. Gliomas with mutated IDH1 and IDH2 have improved prognosis compared with gliomas with wild-type IDH. Mutated IDH can now be detected by immunohistochemistry and magnetic resonance spectroscopy. No drugs currently target mutated IDH, although this remains an area of active research.
Authors:
Adam L Cohen; Sheri L Holmen; Howard Colman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-09-10     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / genetics*
Glioma / genetics*
Humans
Isocitrate Dehydrogenase / genetics*
Mutation / genetics*
Grant Support
ID/Acronym/Agency:
R01 NS073870/NS/NINDS NIH HHS; R01 NS075155/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 1.1.1.41/Isocitrate Dehydrogenase; EC 1.1.1.41/isocitrate dehydrogenase 2, human; EC 1.1.1.42./IDH1 protein, human
Comments/Corrections

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