Document Detail

ICP and CPP: excellent predictors of long term outcome in severely brain injured children.
MedLine Citation:
PMID:  17712566     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children. MATERIALS AND METHODS: ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was >or=40 mmHg for ICP and <or=49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients. CONCLUSION: ICP and CPP are accurate predictors of unfavourable outcome.
B G Carter; W Butt; A Taylor
Related Documents :
18514826 - The role of mechanical ventilation in acute brain injury.
17460816 - Predictive value of initial clinical status, intracranial pressure and transcranial dop...
2679506 - The rational management of idiopathic intracranial hypertension.
8093756 - Complications of intracranial pressure monitoring in fulminant hepatic failure.
8703646 - Effects of the angiotensin type i receptor antagonist, losartan, on systemic and region...
3980366 - Factors influencing regional patency and configuration of the human infant upper airway.
Publication Detail:
Type:  Journal Article     Date:  2007-08-22
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  24     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Rd, Parkville, Melbourne, Victoria, 3052, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Injuries / mortality,  physiopathology*
Cerebrovascular Circulation / physiology*
Child, Preschool
Glasgow Outcome Scale
Intracranial Pressure / physiology*
ROC Curve
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fatty acid signatures of stomach oil and adipose tissue of northern fulmars (Fulmarus glacialis) in ...
Next Document:  The current state of congenital tracheal stenosis.