Document Detail


ICP and CPP: excellent predictors of long term outcome in severely brain injured children.
MedLine Citation:
PMID:  17712566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children. MATERIALS AND METHODS: ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was >or=40 mmHg for ICP and <or=49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients. CONCLUSION: ICP and CPP are accurate predictors of unfavourable outcome.
Authors:
B G Carter; W Butt; A Taylor
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Publication Detail:
Type:  Journal Article     Date:  2007-08-22
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  24     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Affiliation:
Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Rd, Parkville, Melbourne, Victoria, 3052, Australia. icu.tech@rch.org.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain Injuries / mortality,  physiopathology*
Cerebrovascular Circulation / physiology*
Child
Child, Preschool
Glasgow Outcome Scale
Humans
Infant
Intracranial Pressure / physiology*
Prognosis
ROC Curve
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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