Document Detail

ICE-guided patent foramen ovale (PFO) closure with lastest-generation devices: the ideal strategy for PFO-related migraine?
MedLine Citation:
PMID:  17667037     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that the closure of the patent foramen ovale (PFO) may reduce or resolve migrainous symptoms, but ideal indications, devices and techniques are far from being identified definitively. A 21-year-old woman was referred to our center for evaluation of severe migraine (more than two attacks per week, > 6 h in duration, inability to work, direct relationship with Valsalva manouvre and effort, presence of aura), migraine disability assessment questionnaire (MIDAS) score of 42 and a large PFO with no atrial septal aneurysm: on transesophageal echocardiography and instrumental data suggesting a close relationship between migraine and PFO. Having explained the off-label indications for transcatheter PFO closure in this particular case, the patient was recruited for our in-hospital study protocol for assessment for transcatheter closure of PFO to relieve severe migraine and the patient gave consent. A 9-Fr, 9-MHz UltraICE catheter (EP Technologies, Boston Scientific Corporation, San Jose, California, USA) was then inserted through the left femoral vein and a complete intracardiac study was carried out. A 25-mm Premere device was successfully implanted. The patient was discharged the day after being on 75 mg aspirin once a day for 6 months and, at 3-month follow-up, the patient was well with no further migraine attacks (MIDAS score 2). There was no evidence of thrombus formation on the surface of device and no shunt was detected on transesophageal echocardiograhy and transcranial Doppler. Although more clear-cut indications are required, this case study may be the stimulus and basis for further large prospective randomized studies to assess the effectiveness of PFO closure in treating migraine and the best implantation technique and device.
Gianluca Rigatelli; Paolo Cardaioli; Gabriele Braggion; Massimo Giordan; Silvio Aggio; Loris Roncon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  8     ISSN:  1558-2027     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-21     Revised Date:  2009-05-28    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  633-5     Citation Subset:  IM    
Interventional Cardiology Unit, Division of Cardiology, Rovigo General Hospital, Italy.
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MeSH Terms
Cardiac Surgical Procedures / instrumentation*
Coronary Angiography
Heart Catheterization*
Heart Septal Defects, Atrial / complications,  radiography,  surgery*,  ultrasonography
Migraine Disorders / etiology*,  surgery
Prosthesis Design
Prosthesis Implantation / instrumentation*
Radiography, Interventional
Severity of Illness Index
Treatment Outcome
Ultrasonography, Interventional / methods*
Reg. No./Substance:
0/Alloys; 52013-44-2/nitinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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