Document Detail


ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway.
MedLine Citation:
PMID:  16137825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ICAM-3 interacts with LFA1, and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival. It has also been suggested to induce cancer cell proliferation but the precise signaling pathway is unclear. The aim of this study was to determine the ICAM-3-activated downstream pathway in H1299 lung cancer cells. The level of ICAM-3-induced cell growth was examined using BrdU incorporation, which is a colony-forming assay, FACS analysis, and cell counting. The results showed that ICAM-3 expression induces cancer cell proliferation. In addition, FAK, Akt, PDK1, GSK-3beta, BAD, and PTEN were phosphorylated by ICAM-3-overexpression, resulting in enhanced cell proliferation. In conclusion, ICAM-3 expression induces cancer cell proliferation, and an increase in ICAM-3 expression can contribute to cancer progression.
Authors:
Yong Geon Kim; Mi Jin Kim; Jong-Seok Lim; Myeong-Sok Lee; Jun Suk Kim; Young Do Yoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-31
Journal Detail:
Title:  Cancer letters     Volume:  239     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-09-19     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  103-10     Citation Subset:  IM    
Affiliation:
Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / pharmacology*
Apoptosis*
Cell Adhesion Molecules / pharmacology*
Cell Cycle
Cell Proliferation / drug effects*
Colony-Forming Units Assay
Glycogen Synthase Kinase 3 / metabolism
Humans
Lung Neoplasms / metabolism*
Mitogen-Activated Protein Kinase 1 / metabolism
Mitogen-Activated Protein Kinase 3 / metabolism
Mitogen-Activated Protein Kinase Kinases / metabolism
PTEN Phosphohydrolase / metabolism
Phosphatidylinositol 3-Kinases / metabolism*
Phosphorylation / drug effects
Proto-Oncogene Proteins c-akt / metabolism*
Signal Transduction
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Cell Adhesion Molecules; 0/ICAM3 protein, human; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 2.7.11.26/Glycogen Synthase Kinase 3; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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