| ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway. | |
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MedLine Citation:
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PMID: 16137825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ICAM-3 interacts with LFA1, and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival. It has also been suggested to induce cancer cell proliferation but the precise signaling pathway is unclear. The aim of this study was to determine the ICAM-3-activated downstream pathway in H1299 lung cancer cells. The level of ICAM-3-induced cell growth was examined using BrdU incorporation, which is a colony-forming assay, FACS analysis, and cell counting. The results showed that ICAM-3 expression induces cancer cell proliferation. In addition, FAK, Akt, PDK1, GSK-3beta, BAD, and PTEN were phosphorylated by ICAM-3-overexpression, resulting in enhanced cell proliferation. In conclusion, ICAM-3 expression induces cancer cell proliferation, and an increase in ICAM-3 expression can contribute to cancer progression. |
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Authors:
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Yong Geon Kim; Mi Jin Kim; Jong-Seok Lim; Myeong-Sok Lee; Jun Suk Kim; Young Do Yoo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-08-31 |
Journal Detail:
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Title: Cancer letters Volume: 239 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-09-19 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 103-10 Citation Subset: IM |
Affiliation:
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Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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pharmacology* Apoptosis* Cell Adhesion Molecules / pharmacology* Cell Cycle Cell Proliferation / drug effects* Colony-Forming Units Assay Glycogen Synthase Kinase 3 / metabolism Humans Lung Neoplasms / metabolism* Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Mitogen-Activated Protein Kinase Kinases / metabolism PTEN Phosphohydrolase / metabolism Phosphatidylinositol 3-Kinases / metabolism* Phosphorylation / drug effects Proto-Oncogene Proteins c-akt / metabolism* Signal Transduction Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cell Adhesion Molecules; 0/ICAM3 protein, human; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 2.7.11.26/Glycogen Synthase Kinase 3; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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