Document Detail

ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing.
MedLine Citation:
PMID:  19608878     Owner:  NLM     Status:  MEDLINE    
Wound healing and inflammation are both significantly reduced in mice that lack gammadelta T cells. Here, the role of epithelial intercellular adhesion molecule-1 (ICAM-1) in gammadelta T cell migration in corneal wound healing was assessed. Wild-type mice had an approximate fivefold increase in epithelial gammadelta T cells at 24 hours after epithelial abrasion. ICAM-1(-/-) mice had 50.9% (P < 0.01) fewer gammadelta T cells resident in unwounded corneal epithelium, which failed to increase in response to epithelial abrasion. Anti-ICAM-1 blocking antibody in wild-type mice reduced epithelial gammadelta T cells to a number comparable to that of ICAM-1(-/-) mice, and mice deficient in lymphocyte function-associated antigen-1 (CD11a/CD18), a principal leukocyte receptor for ICAM-1, exhibited a 48% reduction (P < 0.01) in peak epithelial gammadelta T cells. Re-epithelialization and epithelial cell division were both significantly reduced ( approximately 50% at 18 hours, P < 0.01) after abrasion in ICAM-1(-/-) mice versus wild-type, and at 96 hours, recovery of epithelial thickness was only 66% (P < 0.01) of wild-type. ICAM-1 expression by corneal epithelium in response to epithelial abrasion appears to be critical for accumulation of gammadelta T cells in the epithelium, and deficiency of ICAM-1 significantly delays wound healing. Since gammadelta T cells are necessary for efficient epithelial wound healing, ICAM-1 may contribute to wound healing by facilitating gammadelta T cell migration into the corneal epithelium.
Sarah E Byeseda; Alan R Burns; Sean Dieffenbaugher; Rolando E Rumbaut; C Wayne Smith; Zhijie Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-16
Journal Detail:
Title:  The American journal of pathology     Volume:  175     ISSN:  1525-2191     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-27     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Movement / genetics,  immunology
Epithelium, Corneal / cytology,  immunology*,  injuries
Intercellular Adhesion Molecule-1 / genetics,  physiology*
Mice, Mutant Strains
Receptors, Antigen, T-Cell, gamma-delta / genetics,  immunology*
T-Lymphocytes / immunology*
Wound Healing / genetics,  immunology*
Grant Support
Reg. No./Substance:
0/Icam1 protein, mouse; 0/Receptors, Antigen, T-Cell, gamma-delta; 126547-89-5/Intercellular Adhesion Molecule-1

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