Document Detail

ICAM-1 deficiency suppresses host allosensitization and rejection of MHC-disparate corneal transplants.
MedLine Citation:
PMID:  10755569     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We used a murine model of orthotopic corneal transplantation to determine whether host deficiency in ICAM-1 promotes survival of corneal grafts with different degrees of allodisparity. METHODS: ICAM-1-/- and wild-type C57BL/6 (ICAM-1+/+) received corneal grafts from the following strains of mice: BALB/c (fully mismatched), BALB.b (mismatched at multiple minor H only), or B10.D2 [including major histocompatibility complex (MHC) mismatch]. Graft rejection, induction of allospecific delayed-type hypersensitivity (DTH) responses, and leukocytic infiltration of grafts were measured. RESULTS: There were no differences in long-term survival of allografts that were either fully mismatched or had only minor H disparity in ICAM-1+/+ vs. ICAM-1-/-hosts. However, whereas B10.D2 grafts were accepted in only 58% of the ICAM-1+/+ hosts, graft survival in ICAM-1-/- recipients was 100% (P=0.006). Moreover, none of the ICAM-1-/- mice receiving B10.D2 grafts developed allospecific DTH. CONCLUSIONS: Prolonged survival seen in MHC-mismatched grafts in ICAM-1-/- mice, along with a suppressed DTH response to donor alloantigens after transplantation, suggest that ICAM-1 is associated with recipient sensitization to MHC alloantigens.
S N Zhu; J Yamada; J W Streilein; M R Dana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transplantation     Volume:  69     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1008-13     Citation Subset:  IM    
Laboratory of Immunology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Blood Group Incompatibility*
Corneal Transplantation / immunology*
Graft Rejection / prevention & control*
Graft Survival
Hypersensitivity, Delayed / immunology,  prevention & control
Intercellular Adhesion Molecule-1 / metabolism*
Isoantigens / immunology*
Major Histocompatibility Complex*
Mice, Inbred Strains
Time Factors
Grant Support
Reg. No./Substance:
0/Isoantigens; 126547-89-5/Intercellular Adhesion Molecule-1

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