| IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. | |
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MedLine Citation:
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PMID: 20651737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis. |
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Authors:
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Mads Gyrd-Hansen; Pascal Meier |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nature reviews. Cancer Volume: 10 ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: England |
Other Details:
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Languages: eng Pagination: 561-74 Citation Subset: IM |
Affiliation:
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Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen DK2200, Denmark. mads.gyrd@bric.ku.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Caspases / antagonists & inhibitors*, physiology Humans Inflammation / etiology* Inhibitor of Apoptosis Proteins / antagonists & inhibitors, chemistry, physiology* Lymphoma, B-Cell, Marginal Zone / etiology NF-kappa B / physiology* Neoplasm Metastasis Neoplasms / etiology*, pathology Signal Transduction Toll-Like Receptors / physiology Ubiquitin / physiology |
| Chemical | |
Reg. No./Substance:
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0/Inhibitor of Apoptosis Proteins; 0/NF-kappa B; 0/Toll-Like Receptors; 0/Ubiquitin; EC 3.4.22.-/Caspases |
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