Document Detail


I405V polymorphism of CETP gene and lipid profile in women with endometriosis.
MedLine Citation:
PMID:  23772784     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.
Authors:
Mehdi Sahmani; Talaat Dabbaghi Ghaleh; Maryam Darabi; Masoud Darabi; Zahra Rashvand; Reza Najafipour
Related Documents :
2937394 - Reproductive endocrine disorders in women with partial seizures of temporal lobe origin.
18672334 - Women with polycystic ovary syndrome are often depressed or anxious--a case control study.
18181084 - Polycystic ovary syndrome and endometrial cancer.
7915824 - A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic am...
18007264 - Evaluation of the effect of intensity of care on mortality after traumatic brain injury.
9376104 - Young people and the structure of sexual risks in lima.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  29     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  712-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry and Genetics, Cellular and Molecular Research Center, Faculty of Medicine, Qazvin University of Medical Sciences , Qazvin , Iran and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oral contraceptive use and measurable cardiovascular risk factors in Korean women aged 20-50 years: ...
Next Document:  Gene receptor polymorphism as a risk factor for BMD deterioration in adolescent girls with anorexia ...