Document Detail


I2-mediated diversity oriented diastereoselective synthesis of amino acids derived trans-2,5-disubstituted morpholines, piperazines and thiomorpholines.
MedLine Citation:
PMID:  22126227     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exo-trig type cyclization from a single common synthetic intermediate. The displacement of iodine with hydride ion gave a methyl substituent at the 2-position of morpholines which provides an additional opportunity for diversity oriented nucleophilic substitution on the rings as well as incorporation of substituents at the 5-position from amino acids constituents.
Authors:
Saurav Bera; Gautam Panda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-29
Journal Detail:
Title:  ACS combinatorial science     Volume:  -     ISSN:  2156-8944     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101540531     Medline TA:  ACS Comb Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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