Document Detail

Hysteroscopy and transvaginal sonography in menopausal women receiving hormone replacement therapy.
MedLine Citation:
PMID:  9132309     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To evaluate the endometrial cavity of menopausal women with irregular bleeding while receiving hormone replacement therapy. DESIGN: Comparative evaluation of hysteroscopic and biopsy findings. SETTING: A center for reproductive studies. PATIENTS: Forty-one patients receiving different regimens of hormone replacement therapy. INTERVENTIONS: Hysteroscopy, endometrial biopsy, and transvaginal sonography were performed in all 41 women. In 10 patients, endometrial polyps were removed with the resectoscope. MEASUREMENTS AND MAIN RESULTS: Irregular bleeding during hormone replacement therapy was associated with atrophic endometrium whenever transvaginal sonography showed endometrial thickness to be less than 4 mm. In patients who developed increased endometrial thickness after hormone replacement therapy, hysteroscopy revealed the presence of endometrial polyps in the uterine cavity. Histopathologic examination of excised polyps revealed cystic or adenomatous hyperplasia confined to these lesions. CONCLUSIONS: Endometrial polyps can appear in menopausal women receiving hormone replacement therapy despite the presence of progestins to oppose the action of estrogens.
H Maia; I C Barbosa; D Marques; L C Calmon; O A Ladipo; E M Coutinho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the American Association of Gynecologic Laparoscopists     Volume:  4     ISSN:  1074-3804     ISO Abbreviation:  J Am Assoc Gynecol Laparosc     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-30     Completed Date:  1997-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9417443     Medline TA:  J Am Assoc Gynecol Laparosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Centro de Pesquisas e Assistencia em Reproducao Humana, Salvador, Bahia, Brazil.
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MeSH Terms
Endometrial Neoplasms / diagnosis,  surgery,  ultrasonography
Endometrium / drug effects,  pathology,  ultrasonography*
Estrogen Replacement Therapy* / adverse effects
Middle Aged
Polyps / diagnosis,  surgery,  ultrasonography
Uterine Hemorrhage / chemically induced,  diagnosis,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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