Document Detail

Hysteroscopic sterilization with occlusion of sheep uterine tube using n-butyl-2-cyanoacrylate adhesive.
MedLine Citation:
PMID:  17923962     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the fertility and analyze the macroscopic, microscopic and morphometric aspects of sheep uterine tube sterilization with a hysteroscopically insert of n-butyl-2-cyanoacrylate adhesive. METHODS: 12 adult sheep, with one previous pregnancy, were distributed as follows: group L (n=3) subjected to laparotomy and Pomeroy uterine tube ligation, group S (n=3) subjected to hysteroscopic application of saline solution in tube isthmus and group AD(n=6), that was subjected to hysteroscopic application of 0.5 ml of n-2-butil-cyanoacrylate in tube isthmus. They were mated with fertile males for ninety days. The non pregnant sheep, at the 90th day, were subjected to laparotomy with uterus and tubes uterine resection. The fragments of uterine tubes were fixated in 10% formalin and processes for histology evaluated, and slices dyes for H.E. Data were evaluated by Wilcoxon and Mann-Whitney and Fisher's exact test. RESULTS: All sheep from groups L and AD did not get pregnant (0%) in contrast with sheep from group S (100%); the adhesive remained integral in the uterine tube lumen. The percentual of adherences (66.6%) and fibrosis responses (100%) was significantly higher in the group L than group AD (0%) (p<0.01). The diameter of the caudal tube in group AD (2652.15 +/- 45.76 mm) was significantly wider than that of the group L (1868.27 +/- 56.11* microm) (p < 0.05). CONCLUSION: The hysteroscopic insertion of cyanoacrylate in the uterine tube lumen of sheep was effective to obstruct the uterine tube and to promote the sterilization.
Sergio Bigolin; Djalma José Fagundes; Henri Chaplin Rivoire; Anna Tereza Negrini Fagundes; Ricardo Simões; Manuel de Jesus Simões
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  22     ISSN:  0102-8650     ISO Abbreviation:  Acta Cir Bras     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-10-09     Completed Date:  2008-09-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Division of Gynecology, Regional Integrated University of High Uruguay and Missions, Rio Grande do Sul, Brazil.
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MeSH Terms
Enbucrilate / analogs & derivatives*,  therapeutic use
Fallopian Tubes* / anatomy & histology
Fertility / drug effects*,  physiology
Fibrosis / etiology
Models, Animal
Sodium Chloride / therapeutic use
Sterilization, Tubal / adverse effects,  methods*
Tissue Adhesions / etiology
Tissue Adhesives / therapeutic use*
Reg. No./Substance:
0/Tissue Adhesives; 6606-65-1/Enbucrilate; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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