Document Detail

Hypoxic ventilatory profile in the anesthetized rat.
MedLine Citation:
PMID:  15611598     Owner:  NLM     Status:  MEDLINE    
In the present study we investigated whether hypocapnia that accompanies hypoxic hyperventilation might affect the biphasic, stimulatory/depressant, ventilatory response to hypoxia. The experiments were carried out in anesthetized, vagotomized, spontaneously breathing, and poikilocapnic rats. The animals were subjected to acute steady-state hypoxia consisting of 12% O(2) in N(2) in inspiratory mixture. Ventilation and its frequency and volume components were assessed from the integrated electromyographic activity of the diaphragm. We found that despite the development of significant hypocapnia, the hypoxic ventilatory response consisted of rapid stimulation followed by a gradual decline. The frequency component contributed more to the ventilatory increase than that of volume. The results indicate that the hypoxic ventilatory profile in the anesthetized poikilocapnic rat resembles that known to be present during isocapnia. We conclude that hypocapnia neither hampers the hypoxic ventilatory reactivity nor alters the biphasic hypoxic ventilatory profile. These observations may aid planning experimental rat model studies.
M Marczak; E E Kolesnikova; M Pokorski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  55 Suppl 3     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-12-21     Completed Date:  2008-01-04     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Department of Respiratory Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland.
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MeSH Terms
Anesthesia / methods*
Anoxia / blood,  physiopathology*
Carbon Dioxide / blood
Hypocapnia / blood,  physiopathology
Models, Animal
Oxygen / administration & dosage,  blood
Partial Pressure
Respiration, Artificial*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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