Document Detail


Hypoxic training increases metabolic enzyme activity and composition of alpha-myosin heavy chain isoform in rat ventricular myocardium.
MedLine Citation:
PMID:  19756706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac muscle adaptation is essential for maintaining physical capacity after ascending to high altitude. This study examines the effects of high altitude training on myocardial metabolic enzyme activity and composition of alpha-myosin heavy chain (MHC). Rats were randomly divided into normobaric sedentary (NS) and training (NT) groups, and hypobaric sedentary (HS) and training (HT) groups. HS and HT rats were exposed to hypobaric hypoxia (simulated 4,000-5,000 m) for 5 weeks (24 h/day), and HT rats simultaneously received swim training. Hypoxia exposure for 5 weeks led to a decrease in succinate dehydrogenase (SDH) and citrate synthase (CS) activities in the left ventricle (LV), and a decrease in CS, hexokinase (HK) and total lactate dehydrogenase (LDH) activities in the right ventricle (RV) (p < 0.05, HS vs. NS). Furthermore, 1 h/day swim training during hypoxia exposure enhanced the CS activity in LV and the SDH and CS activities in RV (p < 0.05, HT vs. HS). The percentages of alpha-MHC in both ventricles in HT were higher than those in HS (p < 0.05). We conclude that exercise training at high altitude is beneficial for cardiac muscle adaptation to hypoxia by increasing activities of enzymes and percentage of alpha-MHC. This may contribute to improved cardiac function and work capacity at high altitude.
Authors:
Ming-Chun Cai; Qing-Yuan Huang; Wei-Gong Liao; Zhou Wu; Fu-Yu Liu; Yu-Qi Gao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-16
Journal Detail:
Title:  European journal of applied physiology     Volume:  108     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology and High Altitude Physiology, Key Laboratory of High Altitude Medicine, Ministry of Educative, Third Military Medical University, Chongqing, China.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Altitude Sickness
Analysis of Variance
Animals
Anoxia / enzymology*,  metabolism,  physiopathology*
Citrate (si)-Synthase / metabolism
Humans
Male
Myocardium / pathology
Myosin Heavy Chains / metabolism*
Myosins / physiology
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Succinate Dehydrogenase / metabolism
Chemical
Reg. No./Substance:
0/Myosin Heavy Chains; EC 1.3.99.1/Succinate Dehydrogenase; EC 2.3.3.1/Citrate (si)-Synthase; EC 3.6.4.1/Myosins

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