Document Detail

Hypoxic response is inversely related to degree of exercise hyperventilation.
MedLine Citation:
PMID:  8525123     Owner:  NLM     Status:  MEDLINE    
The Dejours hyperoxic test has been used to quantitate peripheral chemoreceptor contribution to the hyperpnea of exercise. The strength of this drive, measured by the percent reduction in ventilation, varies among individuals and is lacking in chemodenervated humans, who also fail to manifest a hyperventilatory response in heavy exercise. We reasoned that greater hyperventilation in exercise above the anaerobic threshold ought to be associated with greater hypoxic (carotid body) drive. The present study tested this hypothesis. In 17 naive subjects, carotid body O2 chemosensitivity was tested repeatedly during exercise above the ventilatory anaerobic threshold (VAT) using 2 breaths of O2. The response to these transients was quantitated by the percentage change in ventilation, and exercise hyperventilation was quantitated by VE in excess of VCO2 predicted from the slope of delta VE/delta VCO2 below VAT in incremental exercise. Contrary to expectations, there was an inverse relation between the degree of exercise hyperventilation and the percentage reduction in exercise ventilation in response to O2. The significance of this observation and its integration with current thinking of the role of the peripheral chemoreceptor in mediating hyperventilation of heavy exercise is discussed.
P Pianosi; T Marchione
Related Documents :
2312473 - Effect of caffeine on ventilatory responses to hypercapnia, hypoxia, and exercise in hu...
11303573 - Interaction of nutrient limitation and elevated co2 concentration on carbon assimilatio...
21409403 - Pulmonary oxygen uptake and muscle deoxygenation kinetics during recovery in trained an...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  101     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Dept. of Pediatrics and Child Health, University of Manitoba, Children's Hospital of Winnipeg, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anaerobic Threshold / physiology
Anoxia / physiopathology*
Blood Gas Analysis
Carotid Body / physiology
Exercise / physiology*
Hyperventilation / physiopathology*
Oxygen / blood
Respiratory Mechanics / physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat.
Next Document:  Submental stimulation and supraglottic resistance during mouth breathing.